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- Interacting with various cellular proteins, E6 and E7 influence fundamental cellular human papillomavirus type 16 ncbi like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses.
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Revista Galenus Rezumat Cancerul de col uterin reprezinta a doua cea mai frecventa forma de cancer in randul femeilor, mortalitatea fiind reprezentata de un numar de Virusul raspunzator de aproape toate formle de cancer ano-genital este virusul Papilloma Uman HPVidentificat cu circa de tulpini, atat cu risc ridicat, cat si cu risc redus. Aproximativ 40 de tipuri ale acestui virus, transmise pe cale sexuala, pot infecta zona anogenitala, fiind localizate in keratinocitele in curs de diferentiere. Abstract Cervical cancer is the second most frequent form of cancer among women, killing The virus responsible for nearly all forms of anogenital cancer is Human Papilloma Virus HPVdivided in almost types, from high-risk with carcinogenetic potential to low-risk.
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Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. High-risk E6 human papilloma virus literature E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle. Uncontrolled cell proliferation leads to increased risk of genetic instability. Usually, it takes decades for cancer to develop. This review presents the main mechanisms of HPV genome in the carcinogenesis of the uterine cervix.
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